| 产品名称 |
Recombinant Human GUSB (C-6His) |
| 英文名称 |
GUSB |
| 纯度 |
Greater than 95% as determined by reducing SDS-PAGE |
| 内毒素 |
<1 EU/µg as determined by LAL test. |
| 蛋白构建 |
Recombinant Human Beta-glucuronidase is produced by our Mammalian expression system and the target gene encoding Leu23-Thr651 is expressed with a 6His tag at C-terminus. |
| Accession |
P08236 |
| 表达宿主 |
Human Cells |
| 种属 |
Human |
| 预测分子量 |
73.6 KDa |
| 制剂 |
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH8.0. |
| 运输方式 |
The product is shipped on dry ice/polar packs.Upon receipt, store it immediately at the temperature listed below. |
| 稳定性&储存 |
Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening.Please minimize freeze-thaw cycles. |
| 复溶 |
| 分子别名 |
| Beta-glucuronidase; GUSB; Beta-G1 |
| 背景介绍 |
| Beta-glucoronidase is a lysosomal enzyme catylysing the decomposition of beta-D-glucoronides-compounds arising as a result of the combination of beta-D-glucoronic acid and a number of compounds both exo- and endogenous, containing hydroxylic, carboxylic, amine, imine or thiol groups. Beta-glucuronidase (βGLU)-a lysosomal acid hydrolase responsible for the catalytic deconjugation of β-D-glucuronides has emerged as a viable molecular target for several therapeutic applications. The enzymes activity level in body fluids is also deemed a potential biomarker for the diagnosis of some pathological conditions. The activity of beta-glucoronidase increases in many pathological conditions: liver infammations, cirrhosis of the liver, inflammations of other organs, cholestatic jaundice, tuberculosis, sarcoidosis and also in neoplasms. And many authors point to beta-glucoronidase as a sensitive indicator signalling cell damage. |
注意事项
本司产品仅用于科研，不用于临床诊断和治疗
